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Publications Kurreck 1995-2009

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  • Werk, D.; Pinkert, S.; Heim, A.; Zeichhardt, H.; Grunert, H. P.; Poller, W.; Erdmann, V. A.; Fechner, H.; Kurreck, J. (2009) Synergistic antiviral activity by combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNA. Antiviral Res. 83, 298-306. [pdf full text]
  • Rothe, D.; Werk, D.; Niedrig, S.; Horbelt, D.; Grunert, H. P.; Zeichhardt, H.; Erdmann, V. A.; Kurreck, J. (2009) Antiviral activity of highly potent siRNAs against echovirus 30 and its receptor. J. Virol. Methods 157, 211-218. [pdf full text]
  • Barciszewski, J.; Medgaard, M.; Koch, T.; Kurreck, J.; Erdmann, V. A. (2009) Locked nucleic Acid aptamers. Methods Mol. Biol. 535, 1-22. [pdf full text]
  • Suckau, L.; Fechner, H.; Chemaly, E.; Krohn, S.; Hadri, L.; Kockskamper, J.; Westermann, D.; Bisping, E.; Ly, H.; Wang, X.; Kawase, Y.; Chen, J.; Liang, L.; Sipo, I.; Vetter, R.; Weger, S.; Kurreck, J.; Erdmann, V.; Tschope, C.; Pieske, B.; Lebeche, D.; Schultheiss, H. P.; Hajjar, R. J.; Poller, W. C. (2009) Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation 119, 1241-1252. [pdf full text]
  • Kurreck, J. (2009) RNA interference: from basic research to therapeutic applications. Angew. Chem. Int. Ed. Engl. 48, 1378-1398. [abstract]


  • Dutkiewicz, M.; Grunert, H.-P.; Zeichhardt, H.; Lena, S.; Wengel, J.; Kurreck, J. (2008) Design of LNA-modified siRNAs against the highly structured 5’ UTR of coxsackievirus B3. FEBS Lett. 582, 3061-3066. [pdf full text]
  • Kurreck, J. (2008) Antisense oligonucleotides; antisense strategy; CpG-rich oligonucleotides; gene therapy; gene transfer; Hoogsteen base pairs; triplex-forming oligonucleotides; RNA maturation; RNA processing. In: Müller, S. (Hrsg.) Nucleic Acids from A to Z - a concise encyclopedia. Wiley-VCH, Weinheim.
  • Kurreck, J. (2008) Therapeutic Oligonucletotides. Biomolecular Science Series published by the Royal Society of Chemistry (RSC), Cambridge.
  • Kurreck, J. (2008) The role of backbone modifications in oligonucleotide-based strategies. In: Kurreck, J. (Ed.) Therapeutic Oligonucleotides. Royal Society of Chemistry Publishing, Cambridge, 1-22.
  • Fechner, H.; Kurreck, J. (2008) Vector-mediated and viral delivery of short hairpin RNAs.. In: Kurreck, J. (Ed.) Therapeutic Oligonucleotides. Royal Society of Chemistry Publishing, Cambridge, 267-295.
  • Fechner, H.; Sipo, I.; Westermann, D.; Pinkert, S.; Wang, X.; Suckau, L.; Kurreck, J.; Zeichardt, H.; Müller, O.; Vetter, R.; Tschope, C.; Poller, W. (2008) Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy. J. Mol. Med. 86, 987-997. [pdf full text]
  • Arora, A.; Dutkiewicz, M.; Acaria, V.; Hariharan, M.; Maiti, S.; Kurreck, J. (2008) Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. RNA 14, 1290-1296. [pdf full text]
  • Christoph, T.; Bahrenberg, G.; De Vry, J.; Engleberger, W.; Erdmann, V. A.; Frech, M.; Kögel, B.; Röhl, T.; Schiene, K.; Schröder, W.; Seibler, J.; Kurreck, J. (2008) Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. Mol. Cell. Neurosci. 37, 579-589. [pdf full text]
  • Kurreck, J.; Schubert, S.; Erdmann, V. A. (2008) Antisense-, Ribozym- und RNA Interferenz-Strategien: Methoden des posttranskriptionellen Gene Silencing in der Molekularen Medizin. In: Ganten, D.; Ruckpaul, K. (Hrsg.) Grundlagen der Molekularen Medizin. 3. Auflage, Springer Medizin Verlag, Heidelberg, 410-424.


  • Kurreck, J. (2007) RNA-Interferenz als antivirale Strategie. BIOspektrum 13, 265-267. [pdf full text]
  • Fechner, H. Pinkert, S.; Wang, X.; Sipo, I.; Suckau, L.; Kurreck, J.; Dörner, A.; Sollerbrant, K.; Zeichhardt, H.; Grunert, H.-P.; Vetter, R.; Schultheiss, H.-P.; Poller, W. (2007) Coxsackievirus B3 and adenovirus infections of cardiac cells are efficiently inhibited by vector-mediated RNA interference targeting their common receptor. Gene Ther. 14, 960-971. [pdf full text]
  • Schubert, S.; Rothe, D.; Werk, D.; Grunert, H.-P.; Zeichhardt, H.; Erdmann, V. A.; Kurreck, J. (2007) Strand-specific silencing of a picornavirus by RNA interference: evidence for the superiority of plus-strand specific siRNAs. Antiviral Res. 73, 197-205. [pdf full text]
  • Christoph, T.; Gillen, C.; Mika, J.; Grünweller, A.; Schäfer, K. H.; Schiene, K.; Jostock, R.; Bahrenberg, G.; Weihe, E.; Erdmann, V. A.; Kurreck, J. (2007) Antinoceptive effect of antisense oligonucleotides against VR1/TRPV1, Neurochem. Int. 50, 281-290. [pdf full text]
  • Fechner, H.; Suckau, L.; Kurreck, J.; Sipo, I.; Wang, X.; Pinkert, S.; Loschen, S.; Rekittke, J.; Weger, S.; Dekkers, D.; Vetter, R.; Erdmann, V. A.;  Schultheiss, H.-P.; Paul, M.; Lamers, J.; Poller, W. (2007) Highly efficient and specific modulation of cardiac calcium homeostasis by adenovector-derived short hairpin RNA targeting phospholamban. Gene Ther. 14, 211-218. [pdf full text]


  • Christoph, T.; Grünweller, A.; Mika, J.; Schäfer, M.; Wade, E.; Weihe, E.; Erdmann, V. A.; Frank, R.; Gillen, C.; Kurreck, J. (2006) Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biochem. Biophys. Res. Commun. 350, 238-243. [pdf full text]
  • Röhl, T.; Kurreck, J. (2006) RNA interference and pain research. J. Neurochem. 99, 371-380. [pdf full text]
  • Förster, C.; Brauer, A. B. E.; Brode, S.; Schmidt, K. S.; Perbandt, M.; Meyer, A.; Rypniewski, W.; Betzel, C.; Kurreck, J.; Fürste, J. P.; Erdmann, V. A. (2006) Comparative crystallization and preliminary X-ray diffraction studies of locked nucleic acids and RNA stems of a Tenascin-C binding aptamer. Acta Cryst. F62, 665-668. [pdf full text]
  • Kurreck, J (2006) siRNA efficiency: Structure or sequence - that is the question. J. Biomed. Biotech., Article ID 83757. [pdf full text]
  • Kurreck, J. (2006) Oligonucleotide als zellbiologische Werkzeuge. In: Lottspeich, F.; Engels, J. (eds.) Bioanalytik. Spektrum Verlag, 2. Auflage, Heidelberg, Germany, 979-994.
  • Schubert, S.; Kurreck, J. (2006) Oligonucleotide-based antiviral strategies. In: Erdmann, V. A.; Brosius, J.; Barciszewski, J. (eds.) RNA towards medicine. Handbook of Experimental Pharmacology 173, Springer-Verlag, Berlin / Heidelberg, Gemany, 261-287. [pdf full text]


  • Werk, D.; Schubert, S.; Lindig, V.; Grunert, H.-P.; Zeichhardt, H.; Erdmann, V. A.; Kurreck, J. (2005) Developing an effective RNA interference strategy against a plus-strand RNA virus: Silencing of coxsackievirus B3 and its cognate coxsackievirus-adenovirus receptor. Biol. Chem. 386, 857-863. [pdf full text]
  • Schubert, S. Grunweller, A.; Erdmann, V. A.; Kurreck, J. (2005) Local RNA target structure influences siRNA efficacy:
    Systematic analysis of intentionally designed binding regions. J. Mol. Biol. 348, 883-893. [pdf full text]
  • Schubert, S.; Grunert, H.-P.; Zeichhardt, H.; Werk, D.;  Erdmann, V. A.; Kurreck, J. (2005) Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs. J. Mol. Biol. 346, 457-465. [pdf full text]
  • Zaborowska, Z.; Schubert, S.; Kurreck, J.; Erdmann, V. A. (2005) Deletion study of the 10-23 DNA enzyme. FEBS Lett. 579, 554-558. [pdf full text]


  • Schubert, S.; Kurreck, J. (2004) Ribozyme- and deoxyribozyme strategies for medical application. Curr. Drug Targets. 5 (8), 667-681. [pdf full text]
  • Schmidt, K. S.; Borkowski, S.; Kurreck, J. ; Stephens, A.; Bald, R.; Hecht, M.; Friebe, M.; Dinkelborg, L.; Erdmann, V. A. (2004) Application of Locked Nucleic Acids (LNA) to improve aptamer in vivo stability and targeting function. Nucleic Acids Res. 32, 5757-5765. [pdf full text]
  • Warnecke, C.; Zaborowska, Z.; Kurreck, J.; Erdmann, V. A.; Frei, U.; Wiesener, M.; Eckardt, K.-U. (2004) Differentiating the functional role of hypoxia-inducible factor (HIF)-1and HIF-2 (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2 targe gene in Hep3B and Kelly Cells. FASEB J. 18, 1462-1464. [pdf full text]
  • Schubert, S.; Fürste, J. P.; Werk, D.; Grunert, H.-P.; Zeichhardt, H.; Erdmann, V. A.; Kurreck, J. (2004) Gaining target access for deoxyribozymes, J. Mol. Biol. 339, 355-363. [pdf full text]
  • Poller, W.; Fechner, H.; Kurreck, J.; Pauschinger, M.; Kühl, U.; Erdmann, V. A.; Lamers, J. M. J.; Schultheiss, H.-P. (2004) Nucleic acid-based modulation of cardiac gene expression for the treatment of cardiac diseases. Z. Kardiol. 93, 171-193. [pdf full text]
  • Grünweller, A.; Schubert, S.; Kurreck, J. (2004) Stoppt den Boten - Antisense-, DNA Enzym- und RNA Interferenz-Strategien in der Molekularen Medizin. BIOforum 27, 46-47. pdf full text
  • Kurreck, J. (2004) Antisense and RNA interference approaches to target validation in pain research. Cur. Opinion Drug Discov. Dev. 7, 179-187. [pdf full text]
  • Kurreck, J. (2004) Expediting Target Identification and Validation through RNAi. Exp. Opinion Biol. Ther. 4, 427-429. [pdf full text]


  • Kurreck, J. (2003) Chemie und Biologie von Nucleinsäuren. Angew. Chem. 115, 5542-5543; Nucleic Acids Chemistry and Biology. Angew. Chem. Int. Ed. 115, 5384-5385.
  • Grünweller, A.; Erdmann, V. A.; Kurreck, J. (2003) Cellular uptake and localization of a Cy3 labelled siRNA specific for the serine/Threonine kinase Pim-1. Oligonucleotides 13, 345-352. [pdf full text]
  • Schubert, S.; Gül, D. C.; Grunert, H.-P.; Zeichhardt, H.; Erdmann, V. A.; Kurreck, J. (2003) RNA cleaving "10-23" DNAzymes with enhanced stability and activity. Nucleic Acids Res. 31, 5982-5992. [pdf full text]
  • Grünweller, A.; Wyszko, E.; Bieber, B.; Jahnel, R.; Erdmann, V. A.; Kurreck, J. (2003) Comparison of different antisense strategies in mamalian cells using locked nucleic acids, 2'O-methyl RNA, phosphorothioates and siRNA. Nucleic Acids Res. 31, 3185-3193. [pdf full text]
  • Kurreck, J. (2003) Antisense Technologies: Improvement through novel chemical modifications. Eur. J. Biochem. 270, 1628-1644. [pdf full text]
  • Kurreck, J.; Fürste, J.-P.; Erdmann, V. A. (2003) Ribozyme in der Molekularen Medizin. In: Ganten, D.; Ruckpaul, K. (Hrsg.) Grundlagen der Molekularen Medizin, 2. Auflage, Springer Verlag, Berlin/Heidelberg, 612-630.


  • Zaborowska, Z.; Fürste, J.-P.; Erdmann, V. A.; Kurreck, J. (2002) Sequence requirements in the catalytic core of the ’10-23’ DNA enzyme. J. Biol Chem. 277, 40617-40622.  [pdf full text]
  • Kurreck, J.; Wyszko, E.; Gillen, C.; Erdmann, V. A. (2002) Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res. 30, 1911-1918. [pdf full text]
  • Kurreck, J.; Bieber, B.; Jahnel, R.; Erdmann, V. A. (2002) Comparative study of DNA enzymes and ribozymes against the same full length messenger RNA of the vanilloid receptor subtype I. J. Biol. Chem. 277, 7099-7107.  [pdf full text]


  • Jahnel, R.; Dreger, M.; Gillen, C.; Bender, O.; Kurreck, J.; Hucho, F. (2001) Biochemical characterization of the Vanilloid Receptor 1 expressed in a dorsal root ganglia derived cell line. Eur J. Biochem. 268, 5489-5496.   [pdf full text]


  • Garbers, A.; Kurreck, J.; Iakovleva, O.; Renger, G.; Parak, F. (2001) Mössbauer study of iron centers in D1/D2/Cyt b559 complexes isolated from Photosystem II of spinach. Eur. Biophys. J. 30, 485-493.
  • Kurreck, J.; Schödel, R.; Renger, G. (2000) Investigation of the plastoquinone pool size and fluorescence quenching in thylakoids and Photosystem II (PS II) membrane fragments. Photosynth. Res. 62, 171-182.
  • Kurreck, J.; Niethammer, D.; Kurreck, H. (1999) Primärprozesse der Photosynthese und ihre Modellierung. Chem. unserer Zeit 33, 72-83.
  • Kaminskaya, O.; Kurreck, J.; Irrgang, K.-D.; Owens, T. G.; Renger, G.; Shuvalov, V. A. (1999) Redox and spectral properties of cytochrome b559 in different preparations of PS II. Biochemistry 38, 16223-16235.
  • Toroser, D.; McMichael Jr., R.; Krause, K.-P.; Kurreck, J.; Sonnewald, U.; Stitt, M.; Huber, S. C. (1999) Site-directed mutagenesis of serine 158 demonstrates its role in spinach leaf sucrose-phosphate synthase modulation. Plant J. 17, 407-413.
  • Noguchi, T.; Kurreck, J.; Inoue, Y.; Renger, G. (1999) Comparative FTIR analysis of the microenvironment of QA-  in cyanide-treated, high pH-treated and iron-depleted Photosystem II membrane fragments. Biochemistry 38, 4846-4852.
  • Zech, S. G.; Kurreck, J.; Renger, G.; Lubitz, W.; Bittl, R. (1999) Determination of the distance between Yzox and QA-  in photosystem II by pulsed EPR spectroscopy on light-induced radical pairs. FEBS Lett. 442, 79-82.
  • Garbers, A.; Reifarth, F.; Kurreck, J.; Renger, G.; Parak, F. (1998) Correlation between protein flexibility and electron transfer from QA-  to QB in PS II membrane fragments from spinach. Biochemistry 37, 11399-11404.
  • Zech, S. G.; Kurreck, J.; Eckert, H.-J.; Renger, G.; Lubitz, W.; Bittl, R. (1997) Pulsed EPR measurements of the distance between P680+  and QA-  in Photosystem II. FEBS Lett. 414, 454-456.
  • Kurreck, J.; Garbers, A.; Parak, F.; Renger, G. (1997) Highly purified D1/D2/cyt b559 preparations from spinach do not contain the non heme iron center. FEBS Lett. 403, 283-286.
  • Seeliger, A. G.; Kurreck, J.; Renger, G. (1997) Kinetics of S2 and S3 reduction by Tyrosine YD and other endogenous donors as a function of temperature in spinach PS II membrane fragments with a reconstituted plastoquinone pool. Biochemistry 36, 2459-2464.
  • Kurreck, J.; Seeliger, A. G.; Reifarth, F.; Renger, G. (1997) Investigations on the size and specificity of the plastoquinone pool of Photosystem 2 membrane fragments. Photosynthetica 33, 563-570.
  • Kurreck, J.; Liu, B.; Napiwotzki, A.; Sellin, S.; Eckert, H.-J.; Eichler, H.-J.; Renger, G. (1997) Stoichiometry of pigments and radical pair formation under saturating puls excitation in D1/D2/Cytb559 preparations. Biochim. Biophys. Acta 1318, 307-315.
  • Kurreck, J.; Garbers, A.; Reifarth, F.; Andréasson, L.-E.; Parak, F.; Renger, G. (1996) Isolation and properties of PS II membrane fragments depleted of the non heme iron centre. FEBS Lett. 381, 53-57.
  • Kurreck, J.; Seeliger, A. G.; Reifarth, F.; Karge, M.; Renger, G. (1995) Reconstitution of the endogenous plastoquinone pool in Photosystem II (PS II) membrane fragments, inside-out-vesicles and PS II core complexes from spinach. Biochemistry 34, 15721-15731.


  • Kurreck, J. (2004) Hans Jonas an der Freien Universität Berlin. Erinnerungen eines (ehemaligen) Studenten der Biochemie. In: Böhler, D.; Brune, J. P. (Hrsg.) Orientierung und Verantwortung. Königshausen und Neumann, Würzburg, 519-522.
  • Kurreck, J. (2003) Zwischen Technikoptimismus und Kassandrismus. Synthesis Philosophica 18, 245-272.
  • Kurreck, J. (2002) Die Pflicht zu wissen und das Recht auf Nichtwissen. In: Gronke, H.; Burkhardt, H. (Hrsg.) Philosophieren aus dem Diskurs - Beiträge zur Diskurspragmatik. Königshausen und Neumann, Würzburg, 379-405.
  • Kurreck, J. (1994) Primat der Furcht. Medizinische Gentechnologie und <Prinzip Verantwortung>. In: Böhler, D. (Hrsg.) Ethik für die Zukunft - Im Diskurs mit Hans Jonas. C. H. Beck, München, 428-454.
  • Kurreck, J. (1992) Heuristik der Furcht - Optimismus ohne Illusionen. In: Böhler, D.; Neuberth, R. (Hrsg.) Herausforderung Zukunftsverantwortung - Hans Jonas zu Ehren. Lit Verlag, Münster/Hamburg, 25-26

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